Persistent organic pollutant exposure and thyroid function among 12-year-old children

Background and aim Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) per- polyfluoroalkyl substances (PFASs) are persistent organic pollutants (POPs) globally spread in environment with numerous toxicological properties, including thyroid endocrine disruption. We aimed to assess the associations between various POPs hormones among boys girls aged 12 years, accounting for puberty stages. Methods Exposure 4 PCBs, 3 OCPs 6 PFASs was assessed through blood-serum measurements at age 476 children of PELAGIE mother-child cohort (France). Thyroid function by measuring free triiodothyronine (fT3), thyroxine (fT4) thyroid-stimulating (TSH). Puberty status clinical examination according Tanner Associations were estimated linear regression each hormone (both log-transformed), adjusted potential confounders. levels categorized when a non-linear dose-response relation suggested. Analyses performed (n=227) (n=249) separately. Results Among boys, hexachlorobenzene Perfluorodecanoic acid associated decreased fT3 (β=-0.07 95%CI=[-0.12,-0.02] β=-0.03 95%CI=[-0.06,-0.00] respectively). Perfluorohexanesulfonic (PFHxS) increased fT4, higher beta coefficients 2nd tercile (compared 1st reference). After stratification on pubertal stages, PCBs seemed TSH early group (stages 1 2); but, stage late 5). girls, PFHxS (β=-0.15 95%CI=[-0.29,-0.00]) Perfluorooctanoic (β=-0.06 95%CI=[-0.12,-0.01]). status, no evidence heterogeneity has been observed. Conclusions Consistently literature, this study showed some levels. Furthermore, these heterogenous status. Keywords: pollutant, hormones, adolescence